Md. Mostafizur Rahman Lecturer, Department of Environmental Sciences

Research Interest

I am interested in the field of Toxicology, Molecular biology, pollution remediation and so on. Now, doing some research works on effect of environmental stress on biological systems in Hokkaido University, Sapporo, Japan.

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Conference Papers

Md. Khabir Uddin, Md. Mostafizur Rahman “Separation of Sludge from Textile Effluent by Modified Separation System and Determination of Pollutants Removal Efficiency of the System” Bangladesh Chemical Congress (BCC) 2010, 33rd Annual conference of Bangladesh Chemical Society, Dhaka, Bangladesh.

Taslima Zaman, Md. Mostafizur Rahman, Abdul Kadir Ibne Kamal, Md. Dalower Hossain Rashadur Rahman and Md. Khabir Uddin.2012. Determination of Plant Nutrients and Organic Matter Content in Textile Sludge. Proceedings of the 2nd ICETCESD March 10-12, Sylhet, Bangladesh.

Md. Mostafizur Rahman, Nusrat Jakarin Easha, Taslima Zamanand M Khabir Uddin. 2012 Characterization of Solid Sludge from ETP of Textile Industry; Focusing on the Sustainable Management of Sludge. Proceedings of the An ICGCSD July 14, JSTU, Jessore Bangladesh.

Journals Papers

Cytotoxic effects of cadmium and zinc co-exposure in PC12 cells and the underlying mechanism


Cadmium (Cd2+) is a well studied inducer of cellular necrosis and apoptosis. Zinc (Zn2+) is known to inhibit apoptosis induced by toxicants including Cd2+ both in vitro and in vivo. The mechanism of Zn2+-mediated protection from Cd2+-induced cytotoxicity is not established. In this study, we aimed to understand the effects of Zn2+ on Cd2+-induced cytotoxicity and apoptosis using PC12 cells. Cell viability and DNA fragmentation assays in PC12 cells exposed to Cd2+ and/or Zn2+ revealed that Cd2+ (5 and 10 μmol/L) alone induced significant cell death, and co-exposure to Zn2+ (5, 10, and 100 μmol/L) for 48 h had a protective effect. Assessment of intracellular free sulfhydryl levels and lactate dehydrogenase activity suggested that Cd2+ (10 μmol/L) induced oxidative stress and disrupted cell membrane integrity. Addition of Zn2+ (10 and 100 μmol/L) reduced Cd2+-mediated cytotoxicity. Changes in expression of the apoptotic factors Bax, Bcl-2, Bcl-x, and cytochrome c were measured via western blot and expression of caspase 9 was detected via reverse transcriptase polymerase chain reaction. Western blots showed that Zn2+ (10 and 100 μmol/L) suppressed Cd2+-induced apoptosis (10 μmol/L) by reducing cytochrome c release into the cytosol, and downregulating the proapoptotic protein, Bax. In addition, expression of caspase 9 was lower in Cd2+ (5 μmol/L)-treated PC12 cells when co-treated with Zn2+ (2 and 5 μmol/L). These findings suggest that the effective inhibition of Cd2+-induced apoptosis in PC12 cells by Zn2+ might be due to suppression of mitochondrial apoptosis pathway and inhibition of Cd2+-induced production of reactive oxygen species.

Spatio-temporal assessment and trend analysis of surface water salinity in the coastal region of Bangladesh


The study was designed to collect water samples over two seasons—wet-monsoon season (n = 96) (March–April) and dry-monsoon season (n = 44) (September–October)—to understand the seasonal variation in anion and cation hydrochemistry of the coastal rivers and estuaries contributing in the spatial trend in salinity. Hydrochemical examination of wet-monsoon season primarily revealed Ca–Mg–HCO3 type (66%) and followed by Na–Cl type (17.70%) water. In the dry-monsoon season, the scenario reversed with primary water being Na–Cl type (52.27%) followed by Ca–Mg–HCO3 type (31.81%). Analysis of Cl/Br molar ratio vs. Cl (mg/L) depicted sampling area affected by seawater intrusion (SWI). Spatial analysis by ordinary kriging method confirmed approximately 77% sample in the dry-monsoon, and 34% of the wet-monsoon season had shown SWI. The most saline-intruded areas in the wet-monsoon seasons were extreme south-west coastal zone of Bangladesh, lower Meghna River floodplain and Meghna estuarine floodplain and south-eastern part of Chittagong coastal plains containing the districts of Chittagong and Cox’s Bazar adjacent to Bay of Bengal. In addition, mid-south zone is also affected slightly in the dry-monsoon season. From the analyses of data, this study could further help to comprehend seasonal trends in the hydrochemistry and water quality of the coastal and estuarine rivers. In addition, it can help policy makers to obligate some important implications for the future initiatives taken for the management of land, water, fishery, agriculture and environment of coastal rivers and estuaries of Bangladesh.

Mashura Shammi, Joynal Abedin Bhuiyan, Abdul Kadir Ibne Kamal, Rashedur Rahman, Md. Mostafizur Rahman and M. Khabir Uddin. 2012 Investigation of Salinity Occurrences in Kumar-Madhumati River of Gopalganj District, Bangladesh. Journal of Natural Science and Technology, Canada. (In Press)

Mashura Shammi, Shabnam Mustofa Kanak, Md.Mostafizur Rahman Md. Khabir Uddin. 2012 Community Perceptions of Drinking Water Quality Supplied by DWASA and Economic Impacts of Waterborne Diseases (WBD): A Case Study of Kafrul Thana. Jahangirnagar University Environmental Buletin.Vol.1 P 41-53

Abdul Kadir Ibne Kamal, Md. Mostafizur Rahman, and M. Khabir Uddin. 2011. ‘Influence of Coagulation Process and pH on the Removal of COD and TSS from Textile Effluent’. Bangladesh Journal of Environmental Research. vol. 9,P.49-53