Immunology, Microbiology, Biochemistry.
Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report, we provide evidence that, in spite of an apparent lack of phagocytic activity, basophils can kill bacteria through BET formation
Morshed M, Simon D, Hlushchuk R, Kaufmann T, Eggel A, Walls AF, Obata-Ninomiya K, Karasuyama H, Djonov V, Simon HU, Yousefi S. NADPH Oxidase-Independent Formation of Extracellular DNA Traps by Basophils. J Immunol 2014; 192: 5314-5323
Morshed M, Yousefi S, Stöckle C, Simon HU, Simon D. Thymic stromal lymphopoietin stimulates the formation of eosinophil extracellular traps. Allergy 2012; 67: 1127-1137
Westman M, Saha S, Morshed M, Lampa J. Lack of acetylcholine nicotine alpha7 receptor suppresses development of collagen-induced arthritis and adaptive immunity. Clin Exp Immunol 2010; 162: 62-67